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KMID : 0368019840070020181
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Journal of Soonchunhyang University
1984 Volume.7 No. 2 p.181 ~ p.186
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A Study on the Mechanism of the Cysteine to 2-Cinnamoylthiophene
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Abstract
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The kinetics and mechanism of nucleophilic addition of L-Cysteine to 2 Cinnamoylthiophene over wide pH range wen: presented and analyzed in detail. The rate constants were deter-mined with UV-spectrophotometer in 50% methanol-water solvent at 25°C.
The rate equation which can be applid to over wide pH range was obtained
k= 2.32X104-+-187X10XCOH + 2.12X1OXCOH
3. 17 X 10-2+9. 24 X 102 X COH-]
:4naysis of rate constants suggests that below pH 10, the reaction is initiated by the attack of cysteine molecule, and above pH 12.5, deprotonated cysteine ion attack the molecule.
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